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During 2018, an estimated 85 percent of all prescriptions in the United States were sent electronically, a figure that represents almost 2 billion prescriptions.  That information, included in the Surescripts 2018 National Progress Report, showed a more than 500 percent increase in e-prescribing since 2015, and includes prescriptions for more than 115 million controlled substances.  Each of these e-prescriptions – all 1.91 billion of them – was accompanied by a prescriber’s signature and required a signature at time of pickup.